These are all major advances.

The enemy suffered significant losses.

The age profiles of our societies are changing dramatically.

However, important changes will come quickly.

The most creative breakthroughs became famous events.

How does your brain form its most significant memories? Studies of fear in rats have helped us learn much here.

Here, again, there are considerable drawbacks.

More than 1,400 NGOs operating in 90 countries helped to get 123 countries to ratify the treaty banning landmines.

In cases where household survey data has tracked the same families over time it is common to find considerable churning under the surface.

How does your brain form its most significant memories?

Yet there have also been landmark successes.

The famous ima market suffered some structural damages manipur earthquake pic.twitter.com a2wheI7rkl Яonald Thangeo ( RonaldThangeo) January 4, 2016

There were significant underlying problems, nonetheless.

Although exiting the monetary union would have yielded considerable benefits, Grexit would have entailed sizeable costs as well.

Of course, major systemic disruptions do not occur every year.

Treatment, too, has changed in the wake of the mass poisoning.

Negotiators will also have to overcome significant structural obstacles.

But potentially significant costs offset these small benefits.

Developing countries have already invested heavily in children.

And it, too, would likely yield significant social returns.

But German Chancellor Angela Merkel has undergone a remarkable transformation.

Lisbon Treaty caused significant imbalance between individual institutions.

Instead, the advanced economies need a medium term plan to restore competitiveness and jobs via massive new investments in high quality education, job training and human capital improvements, infrastructure, and alternative renewable energy.

In one stroke, Putin has jeopardized his considerable accomplishments.

The rapid, dramatic shifts brought about by HFT are likely to continue.

The great aquifers that supply water for irrigation are being depleted.

The numbers are considerable. A billion live in the squatter cities now.

But the model also carries considerable costs.

The rapid, dramatic shifts brought about by HFT are likely to continue.

The appropriate response to such massive changes is not protectionism.

But significant obstacles continue to block wider constitutional reform.

But there remain considerable obstacles to fulfilling that commitment.

The city has experienced significant demographic shifts in recent years.

Manitoba has thirty eight public libraries of these, twelve have French language collections and eight have significant collections in other languages.

In many countries, there is considerable scope for domestic resource mobilization.

Without any other compass, the incentive structures they adopted did motivate them not to introduce new products to improve ordinary people lives or to help them manage the risks they faced, but to put the global economy at risk by engaging in short sighted and greedy behavior.

Yet there is abundant distributional change going on under the surface.

But this difference may have less impact than meets the eye.

Abbas, supported by the United States and the European Union, may have control over significant funding.

Major efforts to shift from saving toward spending are also required.

Smaller steps, however, can and should be taken.

So, to go deeper, most biologists have turned to submersibles.

They argued that they had to be richly compensated in order to be motivated.

Among other findings, we documented substantial shortcomings of the app in the area of localization.

To its credit, Turkey has begun to invest heavily in sustainable technologies.