Data obtained from animal experiments show that harmful physiological changes result from the inability of the brain and body to respond to repeated stress with adaptive modifications in structure and function. Three brain areas the hippocampus, the prefrontal cortex, and the amygdala are particularly susceptible to pathological changes in size and function.

Three brain areas the hippocampus, the prefrontal cortex, and the amygdala are particularly susceptible to pathological changes in size and function.